Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 1648 0.0 1.0 0.123 0.211
biological_process el 1648 0.008 1.0 0.617 0.273
biological_process ka 1648 0.0 1.0 0.119 0.212
biological_process rf 1648 0.0 1.0 0.123 0.211
cellular_component ct 1649 0.0 0.981 0.225 0.265
cellular_component el 1649 0.0 1.0 0.446 0.29
cellular_component ka 1649 0.0 0.992 0.229 0.27
cellular_component rf 1649 0.0 0.981 0.225 0.265
disease ct 1462 0.0 1.0 0.044 0.143
disease el 1462 0.0 0.999 0.432 0.297
disease ka 1462 0.0 1.0 0.046 0.154
disease rf 1462 0.0 0.999 0.044 0.143
genetic_interaction ct 1606 0.0 1.0 0.417 0.327
genetic_interaction el 1606 0.0 1.0 0.436 0.32
genetic_interaction ka 1606 0.0 1.0 0.84 0.364
genetic_interaction rf 1606 0.0 1.0 0.424 0.329
molecular_function ct 1634 0.0 0.995 0.266 0.295
molecular_function el 1634 0.0 1.0 0.45 0.268
molecular_function ka 1634 0.0 1.0 0.27 0.3
molecular_function rf 1634 0.0 0.995 0.266 0.295
pathway ct 653 0.001 1.0 0.29 0.333
pathway el 653 0.001 1.0 0.339 0.41
pathway ka 653 0.001 1.0 0.543 0.492
pathway rf 653 0.001 1.0 0.332 0.41
phenotype ct 1480 0.0 0.998 0.076 0.168
phenotype el 1480 0.0 1.0 0.528 0.29
phenotype ka 1480 0.0 1.0 0.075 0.174
phenotype rf 1480 0.0 0.998 0.076 0.168
protein_interaction ct 1657 0.0 1.0 0.07 0.163
protein_interaction el 1657 0.0 0.933 0.065 0.157
protein_interaction ka 1657 0.0 1.0 0.304 0.455
protein_interaction rf 1657 0.0 0.926 0.066 0.154

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 1676 0.0 0.948 0.237 0.266
integration_mean_by_presence el 1676 0.0 0.969 0.428 0.287
integration_mean_by_presence ka 1676 0.0 1.0 0.069 0.154
integration_mean_by_presence rf 1676 0.0 0.942 0.057 0.123
mean ct 1676 0.0 0.948 0.145 0.24
mean el 1676 0.0 0.971 0.209 0.248
mean ka 1676 0.0 1.0 0.042 0.131
mean rf 1676 0.0 0.97 0.046 0.107

CDF plots of non integrated kernels

CDF plots of integrated kernels